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CAS No. 2477812-39-6, Elacestrant Intermediate

  • 2477812-39-6

  • 269.34

  • C17H19NO2

  • Breast Cancer

  • Elacestrant

  • ERα

  • N

Availability:
CAS No. 2477812-39-6, Elacestrant Intermediate

Supply Chain

The Supply Chain Status in China

As of October 8, 2024, there are 12 potential suppliers manufacturing Elacestrant intermediate 6-(2-amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol (CAS No. 2477812-39-6), including 9 factories and 1 lab, among which:

- The 25th percentile has an average registered capital of 1 million CNY;

- The 50th percentile has an average registerd capital of 5.55 million CNY;

- The 75th percentile has an average registered capital of 10 million CNY.

The Demand

We estimate the demand ceiling for this Elacestrant intermediate 6-(2-amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol (CAS No. 2477812-39-6) is:
- Global: 5.452 tons

- US: 0.784 tons

- Europe: 1.366 tons


Feeling overwhelmed? Contact Unibest if you need us to quality-check other sources to strengthen your supply chain or to find a tailored solution for your specific procurement request.


Usage and ROS Analysis


Structure of Elacestrant

Elacestrant API Structure

Elacestrant API is featured with a chiral center. Elacestrant structure is formed by reacting with amine and aldehyde groups.




The Overall Synthesis of Elacestrant API

Elacestrant ROS


There are two essential routes leading to the syntehsis of Elacestrant API. One is from the innovator Radius Pharmaceuticals (lower part of the Elacestrant ROS map) and from a generic-CDMO route. 


The Elacestrant intermediate (6R)-6-(2-amino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol, CAS No. 2477812-39-6 whose racemic form is CAS No. 722520-36-7. It is to be reacted with the achiral moeity CAS No. 2477812-42-1, and forms the N-1 Elacestrant intermediate, which requires further reduction of the ketone group.



Reference


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