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CAS No. 722520-42-5, Elacestrant Intermediate

  • 722520-42-5

  • 297.4

  • C19H23NO2

  • 1.148±0.06

  • 98% min (HPLC)

  • Breast Cancer

  • Elacestrant

  • 1/5/2038 (Elacestrant)

  • ERα

  • N

  • 2023

  • ISO 9001

  • CDMO

Availability:
CAS No. 722520-42-5, Elacestrant Intermediate

Supply Chain

The Supply Chain Status in China

As of October 8, 2024, there are 7 potential suppliers manufacturing Elacestrant intermediate 6-[2-(ethylamino)-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol (CAS No. 722520-42-5), including 5 factories, among which:

- The 25th percentile has an average registered capital of 1 million CNY;

- The 50th percentile has an average registerd capital of 1 million CNY;

- The 75th percentile has an average registered capital of 10 million CNY.


The Demand

We estimate the demand ceiling for this Elacestrant intermediate 6-[2-(ethylamino)-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol (CAS No. 722520-42-5) is:
- Global: 6.901 tons

- US: 0.993 tons

- Europe: 1.729 tons


Feeling overwhelmed? Contact Unibest if you need us to quality-check other sources to strengthen your supply chain or to find a tailored solution for your specific procurement request.


Elacestrant Project Experience


Unibest's Elacestrant Project Experience

For this Elacestrant intermediate 6-[2-(ethylamino)-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol, CAS No.

722520-42-5, our CDMO partner has been producing it since 2022. For hundreds grams of quantity, the production will take place in their lab (ISO 9001 system), whereas for kilograms quantities, the production will be put in the their factory (cGMP system).

Usage and ROS Analysis


Structure of Elacestrant

Elacestrant API Structure

Elacestrant API is featured with a chiral center. Elacestrant structure is formed by reacting with amine and aldehyde groups.




The Overall Synthesis of Elacestrant API

Elacestrant ROS


There are two essential routes leading to the syntehsis of Elacestrant API. One is from the innovator Radius Pharmaceuticals (lower part of the Elacestrant ROS map) and from a generic-CDMO route. 


The Elacestrant intermediate 6-[2-(ethylamino)-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol, CAS No. 722520-42-5, is the racemic form of the chiral moiety CAS No. 3033111-52-0, and DBTA is used for the racemic resolution step. The resultant chiral moeity is to be reacted with the achiral moeity CAS No. 421551-75-9 for futher reactions to free the amine group to be conjugated with an ethyl group.



Reference


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