By selectively targeting the β3-adrenergic receptor, Vibegron exhibits superior efficacy and tolerability compared to traditional OAB medications. With its rapid onset and prolonged duration, Vibegron empowers patients and healthcare providers to manage OAB symptoms with a simplified and effective approach. By integrating Vibegron into your pharmaceutical portfolio, you can expand your impact on patients' quality of life and establish a new standard of care in OAB treatment.

The predominant components of Vibegron, the pyrrolidine imine part with three chiral centers (A), and the pyrrolopyrimidine part with one chiral center(B), are synthesized from specific compounds.

The pyrrolidine imine part (A) is derived from the compound with CAS RN 1295539-30-8, or its Boc-protected alternative, CAS RN 1190391-85-5. Whereas, the pyrrolopyrimidine part (B) can take various acid forms of the current compound or its sodium salt equivalent, CAS RN 1421271-01-3, such as hydrochloride acid, tartaric acid, malic acid, mandelic acid, and maleic acid.

The selection of the sodium salt may require additional acid to extract the pyrrolopyrimidine moiety, potentially adding complexity to your manufacturing process. However, choosing the acid salt forms omits the need for additional acid during handling, thereby easing the route towards commercialization of Vibegron.

References

吕宏海, 郭万成, 房杰, 王国平 & 于振鹏. 一种维贝格龙中间体及其制备方法. (2023).