Targeting CDK4/6 in Cancer Drug Development: Challenges and Opportunities 2023-09-14
The cell cycle is tightly regulated to ensure proper cell division and growth. Cyclin-dependent kinases (CDKs) play a crucial role in controlling cell cycle progression. In particular, CDK4 and CDK6 partner with D-type cyclins during the G1 phase to phosphorylate and inactivate the retinoblastoma (R
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