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CAS No. 127985-74-4, DOTA derivative

  • 127985-74-4

  • C24H33N5O8S

  • 551.61

  • 1.39±0.1

  • 95% min

  • 100 mg

  • ISO9001

  • CDMO

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Product Description

This product, p-SCN-Bn-DOTA, is a bi-functional chelator of DOTA derivative. As a bi-functional chelator, it has been investigated to form a conjugate with long chain fatty acid for myocardial metabolic imaging agents. The DOTA part chelates Ga-67, and the SCN functional group reacts with a modified primary amine on long chain fatty acids for conjugation. 


127985-74-4


DOTA derivative conjugation

src: Price, E. W. & Orvig, C. Matching chelators to radiometals for radiopharmaceuticals. Chem. Soc. Rev. 43, 260–290 (2014).



Reference


Effendi, N. et al. Synthesis and evaluation of radiogallium-labeled long-chain fatty acid derivatives as myocardial metabolic imaging agents. PLoS ONE 16, e0261226 (2021).
Price, E. W. & Orvig, C. Matching chelators to radiometals for radiopharmaceuticals. Chem. Soc. Rev. 43, 260–290 (2014).


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