679406-03-2
C7H6Cl2N2O2
221.04
1.433±0.06
Brown solid
Psoriasis
Deucravacitinib
11/7/2033 (Deucravacitinib)
tyrosine kinase 2
N
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Supply Chain
Based on the proriasis market analysis, the 2023 demand for this intermediate ethyl 4,6-dichloropyridazine-3-carboxylate (CAS No. 679406-03-2) was esimated to range from 3.73 Kg to 4.47 Kg, depending on the specific route. Considering the deeper market penetration and the completion of Deucravacitinib clinical trials on other diseases, the demand is to grow.
As of July 29, 2024, there are 84 potential suppliers manufacturing Deucravacitinib intermediate ethyl 4,6-dichloropyridazine-3-carboxylate (CAS No. 679406-03-2), including 66 factories and 15 labs, among which:
- The 25th percentile has an average registered capital of 1 million CNY;
- The 50th percentile has an average registerd capital of 2 million CNY;
- The 75th percentile has an average registered capital of 10 million CNY.
Feeling overwhelmed? Contact Unibest if you need us to quality-check other sources to strengthen your supply chain or to find a tailored solution for your specific procurement request.
Usage and ROS Analysis
Deucravacitinib, CAS No. 1609392-27-9, is a deuterated compound, and structurally speaking, four scaffolds can be identified:
- a benzene - triazole scaffold (scaffold A)
- a deuterated pyridazine (scaffold B + scaffold C)
- a three membered ring (scaffold D)
This compound, ethyl 4,6-dichloropyridazine-3-carboxylate, CAS No. 679406-03-2, is the pyridazine scaffold (scaffold B) of Deucravacitinib as shown below. It is the chlorinated form of the Deucravacitinib intermediate CAS No. 1352925-63-3. With this compound, your facility does not have to complete a chlorination step using dangerous chlorination reagents such as Phosphorus oxychloride (POCl3).
Two chloride leaving groups on this compound act as the bridges connecting other Decucravacitinib intermediate to form Deucravacitinib API.
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