4-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-4-carboxylic acid, Cas No. 252720-31-3, is a Capivasertib intermediate. It reacts with a common pharmaceutical intermediate
Cas No. 3680-69-1, and forms the Capivasertib intermediate Cas No. 95646-96-1.
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Addie, M. et al. Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases. J. Med. Chem. 56, 2059–2073 (2013).
Lan, R. et al. Aminopyrimidine derivatives for use as modulators of kinase activity. (2013).
Aavula, S. K., Chandukudlu, H. V. K., Chikkulapalli, A. & Chinnakalai, K. Processes for the Preparation of Azd5363 and Novel Intermediate Used Therein. (2015).
Matsunaga, H., Sugihara, T. & Yamada, K. 2,6-Dichloro-8-Iodo-7-Deazapurine for Synthesizing Polysubstituted 7-Deazapurine Derivative. (2016).
Zhou, W. et al. Substrate-controlled Diastereoselective Michael Addition of Alkylidene Malonates by Grignard Reagents. Heterocyclic Communications 25, 116–121 (2019).
Blaquiere, N. A. et al. Compounds and Compositions for the Treatment of Parasitic Diseases. (2021).
Huang, L., Dong, Y., Xu, D., Yue, L. & Li, J. Preparation method of initial amino acid Boc-Pip (Fmoc)-OH. (2023).
![Cas No. 3680-69-1, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine](http://imrorwxhnlprli5q.ldycdn.com/cloud/ljBpqKkrllSRpjomqionip/3680-640-640.gif)
