Tirzepatide intermediate, Tirzepatide main chain, P10, CAS No.2656383-23-0

Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1.

Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose dependent manner.

This Tirzepatide intermediate, CAS No. 2656383-23-0, is a main chain of Tirzepatide. 

Abbreviated as Gly-Pro-Ser(tBu)-Ser(tBu)-Gly-Ala-Pro-Pro-Pro-Ser(tBu)-NH2, it is a ten-peptide (P10), and the corresponding sequence on Tirzepatide is Peptide 30 to Peptide 39.