Tirzepatide intermediate, Tirzepatide main chain, P2, CAS No.186023-44-9

Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1.

Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose dependent manner.

This Tirzepatide intermediate, CAS No. 186023-44-9, is a main chain of Tirzepatide. 

Abbreviated as Fmoc-Ala-Pro-OH, it is a di-peptide (P2), and the corresponding sequence on Tirzepatide is Peptide 35 to Peptide 36.