Tirzepatide intermediate, Tirzepatide main chain, P2, CAS No. 2639221-78-4

Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1.

Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose dependent manner.

This Tirzepatide intermediate, CAS No. 2639221-78-4, is a main chain of Tirzepatide. 

Abbreviated as Boc-Tyr(tBu)-Aib-OH, it is a di-peptide (P2), and the corresponding sequence on Tirzepatide is Peptide 1 to Peptide 2.