Tirzepatide intermediate, Tirzepatide main chain, P4, CAS No. 2682040-93-1

Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1.

Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose dependent manner.

This Tirzepatide intermediate, CAS No. 2682040-93-1, is a main chain of Tirzepatide. 

Abbreviated as Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH, it is a tetra-peptide (P4), and the corresponding sequence on Tirzepatide is Peptide 1 to Peptide 4. 

Tirzepatide is synthesized.

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