Tirzepatide intermediate, Tirzepatide main chain, P4, CAS No.2915356-38-4

Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1.

Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose dependent manner.

This Tirzepatide intermediate, CAS No. 2915356-38-4, is a main chain of Tirzepatide. 

Abbreviated as Fmoc-Ile-Aib-Leu-Asp(OtBu)-OH, it is a four-peptide (P4), and the corresponding sequence on Tirzepatide is Peptide 12 to Peptide 15.