Tirzepatide intermediate, Tirzepatide main chain, P8, CAS No.2461524-68-3

Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1.

Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose dependent manner.

This Tirzepatide intermediate, CAS No. 2461524-68-3, is a main chain of Tirzepatide. 

Abbreviated as Fmoc-Phe-Val-Gin(Trt)-Trp(Boc)-Leu-lle-Ala-Gly-OH, it is an octa-peptide (P8), and the corresponding sequence on Tirzepatide is Peptide 22 to Peptide 29. 

Tirzepatide is synthesized.

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