Tirzepatide intermediate, Tirzepatide side chain, CAS No. 1119061-69-6

Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1.

Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose dependent manner.

This Tirzepatide intermediate, CAS No. 1119061-69-6, is a side chain of Tirzepatide. The IUPAC name is 1-O-tert-butyl 20-O-(2,5-dioxopyrrolidin-1-yl) icosanedioate.

Two hydroxyl groups on the C20 di-fatty acid (CAS No. 2424-92-2, Eicosanedioic acid) are protected by OtBu and OSU groups.