Tirzepatide intermediate, Tirzepatide side chain, CAS No. 1119061-72-1

Tirzepatide is a GIP receptor and GLP-1 receptor agonist. It is a 39-amino-acid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life. Tirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1.

Tirzepatide enhances first- and second-phase insulin secretion, and reduces glucagon levels, both in a glucose dependent manner.

This Tirzepatide intermediate, CAS No. 1119061-72-1, is a side chain of Tirzepatide. The IUPAC name is 1-O-tert-butyl 5-O-(2,5-dioxopyrrolidin-1-yl) (2S)-2-[[20-[(2-methylpropan-2-yl)oxy]-20-oxoicosanoyl]amino]pentanedioate.

Abbreviated as C20-OtBu-Glu(OtBu)-OSU, it contains the C20 fatty acid and Glu. The hydroxyl groups from C20 and Glu are protected.