Eribulin mesylate A, B, C industrialization & kilogram production: 

● A hundred steps of reactions; 

● Achieving chiral impurities < 0.1%, Single impurities 0.5%; 

Prosthetic base induction: 

● Amino acid ligands control through Roche ester; 

● Evans prosthetic base induction; 

Synthetic from natural sources:  

● 28 steps of reaction; 

● Ammonium Phosphate Purification; 

● Achieving chiral impurities < 0.1%, Single impurities 0.5% in poly chirality situation; 

● Hundred-gram production;