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CAS No. 1146629-83-5, (R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

  • 1146629-83-5

  • C11H14BrN3

  • 268.15

  • 1.51±0.1

  • 98.0% min (HPLC); 99.8% e.e min (HPLC)

  • Light yellow solid

  • Polycythemia Vera

  • Ruxolitinib

  • 5/5/2041 (Ruxolitinib)

  • JAK1 and JAK2

  • N

  • 100 kg Batch quantity

  • 60 kg

  • 2022

  • ISO 9001

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Product Description

This product, CAS No. 1146629-83-5, is a key Ruxolitinib intermediate for Suzuki coupling with another key -tinib intermediate CAS No. 3680-69-1. The bromo leaving group can be further replaced by boron compounds such as Bis(pinacolato)diboron or Triisopropyl borate, providing a site for carbon-carbon bond formation.


Suzuki coupling in the synthesis of Ruxolitinib


References




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CAS No. 1146629-83-5 Ruxolitinib intermediate