Cas No. 591769-05-0, 3-Cyclopentylacrylonitrile

CAS No.:
591769-05-0
Molecular Formula:
C8H11N
Molecular weight (g/mol):
121.18
Density (g/ml):
1.027±0.06
Purity:
98% min (GC)
Flash Point (°C):
79.9
Physical Properties:
Colorless transparent liquid
Indications:
Polycythemia Vera
API Name:
Ruxolitinib
Last Drug Patent Expires:
5/5/2041 (Ruxolitinib)
Target:
JAK1 and JAK2
Dangerous Goods (Y/N):
N
Stock situation:
500 kg
Factory annual outcome:
20 t
Year of start producing:
2016
Factory system:
GMP; ISO 9001; ISO 45001; FSSC 22000; Kosher; Halal

Availability:



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Product Description

This product, CAS No. 591769-05-0, is a key Ruxolitinib intermediate in an alternative route. It reacts with Ruxolitinib intermediate CAS No. 941685-27-4 to form a racemic Ruxolitinib API free base, which is SEM-protected in the following reaction scheme. Although one can potentially lead the synthesis plan from CAS No. 591769-05-0 and form the chrial center first, we suggest the route with CAS No. 941685-27-4 because this route avoids the use of a several dangerous and controlled substances such as methanesulfonyl chloride CAS No. 124-63-0.

alternative route