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Cas No. 591769-05-0, 3-Cyclopentylacrylonitrile

  • 591769-05-0

  • C8H11N

  • 121.18

  • 1.027±0.06

  • 98% min (GC)

  • 79.9

  • Colorless transparent liquid

  • Polycythemia Vera

  • Ruxolitinib

  • 5/5/2041 (Ruxolitinib)

  • JAK1 and JAK2

  • N

  • 500 kg

  • 20 t

  • 2016

  • GMP; ISO 9001; ISO 45001; FSSC 22000; Kosher; Halal


Product Description

This product, CAS No. 591769-05-0, is a key Ruxolitinib intermediate in an alternative route. It reacts with Ruxolitinib intermediate CAS No. 941685-27-4 to form a racemic Ruxolitinib API free base, which is SEM-protected in the following reaction scheme. Although one can potentially lead the synthesis plan from CAS No. 591769-05-0 and form the chrial center first, we suggest the route with CAS No. 941685-27-4 because this route avoids the use of a several dangerous and controlled substances such as methanesulfonyl chloride CAS No. 124-63-0.

alternative route


Zhang, X. et al. Synthesis Process of Ruxolitinib. (2019).