1346623-11-7
C25H29FN2O3
424.5
1.264±0.06
98% min (HPLC)
white solid
Anti-Neutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis
Avacopan
Complement 5a Receptor
N
2023
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Product Description
This product, CAS No. 1346623-11-7, is an intermediate of Avacopan. Unibest has supplied this product to a generic drug company giant in 2023. In the ROS published by Teva, CAS No. 1346623-11-7 is chlorinated to form CAS No. 2969217-10-3, which reacts with CAS No. 65934-74-9 to generate Avacopan API.
In the lab scale, the synthesis of this product is hindered by the hydrogenation step, which requires multiple reactors. However, under industrial scale, the hydrogenation step can be efficiently processed at the manufacturing site.
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