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Cas No. 941685-27-4, 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

  • 941685-27-4

  • C15H21N5OSi

  • 315.45

  • 1.20±0.1

  • 98%~102%

  • White to pink powder

  • Ruxolitinib, Baricitinib

  • 5/5/2041 (Ruxolitinib); 11/30/2032 (Baricitinib)

  • JAK1 and JAK2

  • N

  • 30 kg

  • 10 t

  • 2017

  • GMP; ISO 9001


Product Description

This product, CAS No. 941685-27-4, is a key Ruxolitinib intermediate in an alternative route that is SEM-protected. It reacts with another Ruxolitinib intermediate CAS No. 591769-05-0 to form a racemic Ruxolitinib API free base, which is SEM-protected. Although one can potentially lead the synthesis plan from CAS No. 591769-05-0 and form the chrial center first, we suggest the route with this compound CAS No. 941685-27-4 because this route avoids the use of a several dangerous and controlled substances such as methanesulfonyl chloride CAS No. 124-63-0.

alternative route


Zhang, X. et al. Synthesis Process of Ruxolitinib. (2019).