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![Cas No. 941685-27-4, 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine](http://imrorwxhnlprli5q.ldycdn.com/cloud/lpBpqKkrllSRpjommiqpip/941685.gif) |
![Cas No. 941685-27-4, 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine](http://imrorwxhnlprli5q.ldycdn.com/cloud/lpBpqKkrllSRpjommiqpip/941685-100-100.gif)
941685-27-4
C15H21N5OSi
315.45
1.20±0.1
98%~102%
White to pink powder
Ruxolitinib, Baricitinib
JAK1 and JAK2
N
30 kg
10 t
2017
GMP; ISO 9001
![Cas No. 941685-27-4, 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine](http://imrorwxhnlprli5q.ldycdn.com/cloud/lpBpqKkrllSRpjommiqpip/941685-800-800.gif)
Product Description
This product, CAS No. 941685-27-4, is a key Ruxolitinib intermediate in an alternative route that is SEM-protected. It reacts with another Ruxolitinib intermediate CAS No. 591769-05-0 to form a racemic Ruxolitinib API free base, which is SEM-protected. Although one can potentially lead the synthesis plan from CAS No. 591769-05-0 and form the chrial center first, we suggest the route with this compound CAS No. 941685-27-4 because this route avoids the use of a several dangerous and controlled substances such as methanesulfonyl chloride CAS No. 124-63-0.
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