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Cas No. 956460-96-1, Capivasertib intermediate

  • 956460-96-1

  • C17H23N5O4

  • 361.4

  • 1.37±0.1

  • Breast Cancer

  • Capivasertib

  • Serine/Threonine Kinase

  • N

  • CDMO

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Cas No. 956460-96-1, Capivasertib intermediate

Product Description

4-[(2-methylpropan-2-yl)oxycarbonylamino]-1-(7 H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid, Cas No. 956460-96-1 is a Capivasertib intermediate. The carboxyl group reacts with the key Capivasertib intermediate Cas No. 886061-26-3.


It can be formed by the reaction of Cas No. 252720-31-3 and a common pharmaceutical intermediate Cas No. 3680-69-1.

Capivasertib key intermediates



References

Tse, M. K. et al. Ruthenium‐Catalyzed Asymmetric Epoxidation of Olefins Using H 2 O 2 , Part I: Synthesis of New Chiral N , N , N ‐Tridentate Pybox and Pyboxazine Ligands and Their Ruthenium Complexes. Chemistry A European J 12, 1855–1874 (2006).
 


Woodhead, S. J. et al. Substituted Piperidines Containing a Heteroarylamide or Heteroarylphenyl Moiety. (2008).

 


Johnson, P. D., Leach, A., Luke, R. W. A., Matusiak, Z. S. & Morris, J. J. Pyrrolo [2, 3 -D] Pyrimidin Derivatives as Protein Kinase B Inhibitors. (2009).

 


Addie, M. et al. Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases. J. Med. Chem. 56, 2059–2073 (2013).


Lan, R. et al. Aminopyrimidine derivatives for use as modulators of kinase activity. (2013).


Aavula, S. K., Chandukudlu, H. V. K., Chikkulapalli, A. & Chinnakalai, K. Processes for the Preparation of Azd5363 and Novel Intermediate Used Therein. (2015).


Matsunaga, H., Sugihara, T. & Yamada, K. 2,6-Dichloro-8-Iodo-7-Deazapurine for Synthesizing Polysubstituted 7-Deazapurine Derivative. (2016).


Zhou, W. et al. Substrate-controlled Diastereoselective Michael Addition of Alkylidene Malonates by Grignard Reagents. Heterocyclic Communications 25, 116–121 (2019).


Blaquiere, N. A. et al. Compounds and Compositions for the Treatment of Parasitic Diseases. (2021).


Huang, L., Dong, Y., Xu, D., Yue, L. & Li, J. Preparation method of initial amino acid Boc-Pip (Fmoc)-OH. (2023).


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