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Unibest NewCo & Licensing Pipeline

Views: 1778     Author: Unibest Industrial     Publish Time: 2025-09-30      Origin: Site

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Last Updated: 2025-09-30

ADC

CodeTargetIndicationPreclinicalPh IPh IIPh IIINDA/BLADetail
UB391Her2/Her2Breast Cancer/esophagogastric cancer/NSCLC

UB319ROR1, DNA Topoisomerase IAdvanced solid tumor as monotherapy

UB320ROR1, DNA Topoisomerase IDLBCL as combination therapy

UB318ROR1, DNA Topoisomerase IMCL, DLBCL, cHL as monotherapy

UB390ROR1Solid tumors/hematological malignancies

UB044Microtubule (ADC payload)HER2- breast cancer; HER2+ gastric cancer

UB322MUC17, DNA Topoisomerase IAdvanced solid tumor

UB323FGFR2b, DNA Topoisomerase IAdvanced solid tumor

UB321CDH17, DNA Topoisomerase IGI cancer

UB394GPC3Solid tumors

UB392CLDN6Solid tumors

UB393ITGB6Solid tumors

UB031cMet/HER2Pancreatic cancer; lung cancer; gastrointestinal cancer; renal cancer

UB032Nectin-4/Trop2Bladder cancer; cervical cancer; lung cancer

UB022HER2/Trop2Breast cancer; cervical cancer; gastric cancer

UB127EGFR;cMetLung Cancer

UB126ADAM9Gastrointestinal Cancer

UB134EGFR Bi-epitope + Dual-payloadCRC,HNSC,PAAD,NSCLC,etc.

UB189B7H3 BsAb + Dual-payloadSCLC

UB188DLL3 BsAb + Dual-payloadSCLC; neuroendocrine neoplasm

UB136BsAb + Dual-payloadSolid tumors

UB138Undisclosed (BsAb+Dual-payload)Solid tumors

UB137Undisclosed (mAb+Dual-payload)Solid tumors

UB191TROP2 BsAb + Dual-payloadPancreatic cancer

UB190B7H3 Bi-functional+ Dual-payloadProstate cancer

Antibody

CodeTargetIndicationPreclinicalPh IPh IIPh IIINDA/BLADetail
UB187PD1Recurrent or metastatic thymic carcinoma that has failed first-line chemotherapy

UB186EGFRColorectal cancer

UB302VEGF-AMoist age-related macular degeneration

UB053PDL1; 4-1BBExtrapulmonary Neuroendocrine Carcinomas

UB335IL-6RRA (Rheumatoid arthritis)

UB330IL-4RαPrutigo nodularis

UB336IL-6RiMCD (Idiopathic multicentric castleman disease)

UB331IL-4RαAtopic dermatitis

UB056PDL1; 4-1BBNSQ-NSCLC; NSCLC; biliary cancer; solid tumor (+ radiotherapy; +/- VEGF)

UB055PDL1; 4-1BBExtrapulmonary Neuroendocrine Carcinomas; NSCLC (+ radiotherapy)

UB054PDL1; 4-1BBNSCLC; biliary cancer; solid tumor

UB013LAG3Solid tumors and lymphoma; autoimmune

UB014EGFR; CD3Metastatic breast cancer; gastric cancer

UB396EGFR/cMetSolid tumors

UB408BCMA/CD3MM, AL amyloidosis

UB149AβAlzheimer's Disease

UB058GPRC5D; CD3MM

UB060MUC16; CD3Ovarian cancer; cervical cancer; solid tumor

UB385IL36RAutoimmune

UB015EGFR; CD3 (enzyme-controlled)Solid tumors

UB019GPC3; CD3Hepatocellular carcinoma

UB017IL-12 prodrugSolid tumors

UB266CD38Multiple myeloma

UB059GPRC5D; CD3MM (US)

UB061MUC16; CD3Solid tumor (US)

UB332(BsAb)IBD, PsO, PsA

UB333(BsAb)IgA nephropathy

UB340TL1AIBD (UC + CD); systemic sclerosis

UB342TL1A, TNF-αIBD; RA

UB344IL-6R, IL-23p19RA; TED; CKD; ASCVD

UB341TL1A, IL-23p19IBD; psoriasis

UB343TL1A, IL-6RIBD; TED

UB345IL-6R, TNF-αUveitis; NMOSD; dental caries

UB018RORI; CD3Lymphoma; breast cancer

UB041HERV-K Env-TMAll cancer

UB023PD-L1; VEGFLung cancer; breast cancer

UB267CD38Multiple myeloma

UB020PD-1/IL-15 cytokine antibody conjudgateSolid tumors

UB057PDL1; 4-1BBSolid tumor (US)

UB377ActRIIA/BObesity

CGT

CodeTargetIndicationPreclinicalPh IPh IIPh IIINDA/BLADetail
UB098HBVHepatocelluar Carcinoma

UB084(Oncolytic virus)Metastatic refractory tumors, including squamous cell carcinoma of the head and neck, lung cancer, ovarian cancer, sarcoma, triple-negative breast cancer, and other sensitive tumors.
About
UB038TGFβ1; COX-2 (siRNA)NMSC

UB144(siRNA)Solid tumors

UB139PCSK9 (siRNA)Hypercholesteremia

UB145Factor XI (siRNA)Anticoagulation, Stroke

UB354
VZV

UB099HBVCholangio-carcinoma

UB039TGFβ1; COX-2 (siRNA)Focal Fat Reduction

UB085(Oncolytic virus)Metastatic refractory tumors, including squamous cell carcinoma of the head and neck, lung cancer, ovarian cancer, sarcoma, triple-negative breast cancer, and other sensitive tumors. （US）
About
UB140PCSK9 (siRNA)Hypercholesteremia

UB101HPVCervical, Head & Neck Cancer

UB100HBVChronic Hepatitis B

UB356
Personalized Tumor mRNA Vaccine (PCV)

UB355
TB

UB092(siRNA)Age-related macular degeneration

UB097(siRNA)Melanoma

UB089IL4R (siRNA)Atopic dermatitis

UB090Calcineurin/Fn14 (siRNA)Organ transplant; autoimmune

UB146ApoC3 (siRNA)Hypertriglyceridemia

UB103(iPSC)Solid tumor

UB095(siRNA)Nephrotic syndrome

UB096SGLT2 (siRNA)Type 2 Diabetes; ghout

UB102EBVSolid tumor

UB094FcRn (siRNA)Myasthenia gravis

UB091Glucosylceramide synthase (siRNA)Gaucher/Fabry

UB093Renin / AGTHypertension

Fusion Protein

CodeTargetIndicationPreclinicalPh IPh IIPh IIINDA/BLADetail
UB326FGF21R, GCGR, GLP-1 RSevere hypertriglyceridemia

UB325FGF21R, GCGR, GLP-1 RMAFLD

UB350GLP-1, GLP-2Obesity; T2D

UB351GLP-1, GLP-2Obesity

UB327PDL1, VEGF, TGFβNSCLC

UB337CD80, CD86RA; SLE; GvHD

UB329CLDN18.2Advanced solid tumor

UB328PDL1, VEGF, TGFβGI cancer

UB338IL-1R1Cryopyrin-associated periodic syndromes; gout arthritis

UB352αActRII, αMyostatinObesity (muscle enhancer)

Peptide

CodeTargetIndicationPreclinicalPh IPh IIPh IIINDA/BLADetail
UB011GLP-1 RDiabetes

UB298Insulin receptorType 2 diabetes

UB080GLP-1Obesity

UB316GLP-1; GIPDiabetes

UB315GLP-1; GIPWeight management

UB081GLP-1MASH

UB012GLP-1 RObesity

UB045GLP-1Type 2 Diabetes (US)

UB047GLP-1;GCGObesity

UB285Tumor neuantigensPancreatic cancer (personalized cancer vaccaine)

UB049μ opioid receptorOIC

UB048GLP-1;GCGMASH (US)

UB263GLP-1 RCVOT in T2DM

UB046GLP-1Type 2 Diabetes + SGLT-2

UB050GCGRCongenital hyperinsulinism

UB317GLP-1; GIPMAFLD/MASH, OSA, HFpEF

UB051GLP-1; GIPType 2 Diabetes; Obesity; MASH

UB052GLP-1R; GIPR; GCGRType 2 Diabetes; Obesity; MASH

UB104GLP-1 (Oromucosal)Diabetes; Obesity
About
UB010GLP-1 RDiabetes

Biologics

CodeTargetIndicationPreclinicalPh IPh IIPh IIINDA/BLADetail
UB339TregIBD; ALS; SLE

Small Molecule

CodeTargetIndicationPreclinicalPh IPh IIPh IIINDA/BLADetail
UB202Lanosterol 14-alpha demethylaseInvasive aspergillosis and mucormycosis
ANDA

UB226β2 AR, Glucocorticoid receptorAsthma and COPD
ANDA

UB228CHRM3COPD
ANDA

UB311Free radical scavengerCerebral ischemic stroke

UB082F protein (RSV)RSV

UB066P2Y12RIS (Ischemic stroke)

UB065P2Y12RACS

UB314EGFR (L858R)NSCLC

UB395CDK2/4/6Breast Cancer

UB360P2Y12RPAD (peripheral arterial disease)

UB365TRKA (Gel)Inflammatory skin disease pruritus

UB309JAK1, JAK2Vitiligo

UB312GLP-1 (oral)Weight management

UB313GLP-1 (oral)Diabetes

UB384PDE3/4COPD

UB361JAK1 (oral)AD (Moderate to severe atopic dermatitis)

UB353SYK inhibitorImmune Thrombocytopenia

UB063HBV CaspidCHB (Chronic Heptitis B)

UB068JAK1 (oral)AS (Ankylosing spondylitis)

UB310JAK1, JAK2Prutigo nodularis

UB0425-HT; DAASD

UB347Core Protein CpAMHBV

UB386AT2RChronic post-stroke pain

UB362JAK1 (oral)Vitiligo

UB348Surface Antigen HBsAgHBV

UB067JAK1 (Gel)AD (Mild to moderate atopic dermatitis)

UB062KCNQ2/3Epilepsy (AU)

UB024KV1.3 (Topical)Atopic dermatitis
About
UB147Keratin, PlasminMelasma

UB364JAK1 (oral)RA

UB363JAK1 (oral)IBD

UB349ASK-1NASH & Fibrosis

UB176KV1.3 (Topical)Psoriasis
About
UB083F protein (RSV)RSV prevention

UB069RIPK1Peripheral arterial diseases; primary biliary cirrhosis

UB064TEADOncology

UB027mTORC2Neuroendocrine tumors; lung cancer; breast cancer

UB397EGFRLung Cancer

UB388ARmCRPC

UB387BTKhematological malignancy

UB026PI3K-Akt-mTOR pathwayMelanoma; esophageal cancer, colorectal cancer

UB028FXIaThrombus

UB284AChEMyasthemia gravis

UB029KV1.3 (Oral)Inflammatory bowel disease
About
UB030cMyc pathwayGynecological tumors

UB389ERHR+/HER2- breast cancer

UB148Androgen receptorAcne

UB177KV1.3 (Oral)Atopic dermatitis
About
UB398Pan KRASSolid tumors

UB404MENINhematological malignancy

UB401USP1Solid tumors

UB400PARP1Solid tumors/ Brain metastasis

UB376GLP-1RObesity

UB070pan-RAS (on)Solid tumor

UB367IL-17Psoriasis

UB368BTK-PROTACSLE、AD

UB040Multiple targets; immunostimulantsAll cancer

UB180GPCROcular inflammatory diseases

UB182Ion channel inhibitorPruritus

UB183Ion channel inhibitorDiabetic nephropathy

UB043Agmatinase, Imidazoline Rc, NMDA RcASD

UB125GABAA ReceptorEpilepsy

UB372WRNSolid tumor

UB371MAT2APan-tumor

UB370ATMSolid tumor

UB369ER-PROTACBreast cancer

UB179GPCRDiabetic retinopathy; age related macular degeneration

UB181GPCRCOPD

UB178KV1.3 (Topical)Alopecia
About
UB366TRKA/B/CNTRK Fusion mutant solid tumor

UB229Glucocorticoid receptor, CHRM3, β2 ARCOPD

UB383VAV1Autoimmune

UB375
Muscle building/Weight loss

UB379AMYRObesity/Diabetes

UB380GIPRDiabetes

UB381STAT6Autoimmune\Respiratory

UB382NEK7-MGDAutoimmune

UB373
IBD

UB374
Diabetes/Obese

UB378ActRIIBObesity

UB402PRMT5Solid tumors

UB403POLQSolid tumors

UB405BTKCLL/SLL DLBCL

UB399Pan RASSolid tumors

UB406KEAP1Solid tumors

UB407WFS1Solid tumors

Targeted Protein Degradation

CodeTargetIndicationPreclinicalPh IPh IIPh IIINDA/BLADetail
UB324HPK-1Advanced solid tumor

UB025cMycPancreatic cancer
About

NewCo license out antibody small molecule ADC recombinant protein CGT targeted protein degradation